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by Ken Ingham

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Curriculum Vitae
Kenneth C. Ingham, PhD

B.S. in Chemistry & Mathematics, Eastern Michigan University, 1965
Ph.D. in Physical Chemistry, University of Colorado, 1970

Professional History:
1970-1972 Fellow, Depts of Biophys & Biochem, Michigan State U
1972-1975 Sr. Fellow, National Institutes Health (NIAMD)
1975-2004 Scientist, Am Red Cross Blood Services, Bethesda, MD
1983-1984 Visiting Scientist, Biozentrum, U of Basel, Switzerland
1985-2004 Head, Biochem Dept, Am Red Cross, Rockville, MD
1988-2004 Prof of Biochem and Molec Biol, George Washington U

Fogarty International Fellowship, 1983-84,
Research Career Development Award, NHLBI, 1977-82

Professional Societies:
American Society of Biological Chemists
Biophysical Society
International Society of Thrombosis and Hemostasis
The Protein Society
International Society of Biorecognition Technology

External Appointments and Committees:
Molecular and Cellular Biophysics Study Section, NIH (l981-85)
Ad Hoc, Biomed Science Fellowship Review, NIH (1980;1983)
Site-Visitor, NHLBI Prog Proj Review, Temple University, Thrombosis & Hemostasis, December 1985
Site-Visitor, NIGMS Prog Proj Review, Albany Medical Center, Tissue Injury and Repair, 1988
Faculty Member, Fdn. Adv. Educ. Sciences, NIH (1978-83)
Member, Molecular Sciences Review Panel, NSF, 1989
Exchange Scientist, Inst. of Biochemistry, Ukranian Academy of Science, Kiev (1989;1991)
Member, Biochemistry of Fibrinolysis Study Section, NIH, 1990
Site-Visitor, NHLBI Prog Proj Review, U of Wisc Milwaukee, Structure & Function of Clotting Proteins, 1991
Site-Visitor, NHLBI Prog Proj Review, U of Rochester, Basic and Clinical Studies of Coagulation Proteins, 1993
Ad Hoc, Molecular and Cellular Biophysics Study Section, NIH, 1994
Ad Hoc, Heme-1 Study Section, NIH (1995)
Site-Visitor, NIGMS Prog Proj Review, Albany Medical Center, Wound Healing, 1996
Member Editorial Board, Archives of Biochemistry Biophysics, 1998-2004

Internal Committees:
Chair, Seminar Committee, ARC Blood Services (1976-1981; 92-93; 97-98)
Chair, Plasma Fractionation Task Force, ARC Blood Services (1977-82)
Chair, Viral Inactivation Task Force, ARC Blood Services (1981-84)
Chair, Radiation Safety Committee, ARC Holland Labs (1988-91)
Member, Vivarium Advisory Committee, ARC Holland Labs (1998-00)

Research Grants:
Subunit Interactions in Glycoprotein Hormones, NIAMDD (1977-80)
Precipitation of Proteins with Poly(ethylene glycol),NHLBI (1977-80)
Physical Chemistry of Therapeutic Plasma Proteins, NHLBI (1981-91)
Shared Instrumentation Grant, NHLBI (1988)
Domain Structure of Plasma Proteins, Mathers Fndn (1990-95)
Molecular Interactions of Fibronectin, NHLBI (1990-95)
Protein and Nucleic Acid Core Facility, NHLBI (1990-95)
Domain Structure and Interactions of Fibronectin, NHLBI (1992-97)
Domain Structure of Integrin IIbIIIa, Fogarty Internat Cntr (1993-96)
Interactions of Fibronectin Modules, NHLBI (1997-2002)

Selected Publications:
1. Ingham, K.C. and Strickler, S.J. (1970) Hindered Internal Rotation in the Ground and Excited Electronic States of Ortho-Xylene, J. Chemical Physics 53,4313- 4318.
3. Ingham, K.C. (1971) The Role of Non-Bonded Forces in Barriers to Internal Rotation in Molecules with Two Equivalent Methyl Groups, J. Phys. Chem. 76,551-553.
6. Ingham, K.C. and El-Bayoumi, M.A. (1974) Photo-induced Double Proton Transfer in a Model DNA Base Pair; J. Am. Chem. Soc. 96,1674-1682.
11. Ingham, K.C., Saroff, H. and Edelhoch, H. (1975) Ligand Induced Self-Association of Human Chorionic Gonadotropin: Positive Cooperativity in the Binding of 1,8- Anilinonaphthalene Sulfonate, Biochemistry 14, 4751-4758.
13. Ingham, K.C., Weintraub, B.D. and Edelhoch, H. (1976) Kinetics of Recombination of the Subunits of Human Gonadotropin. Effect of Subunit Concentration, Biochemistry 15,1720-1726.
19. Miekka, S.I. and Ingham, K.C. (1978) Influence of Self-Association of Proteins on Their Precipitation by Poly(ethylene glycol), Arch. Biochem. Biophys. 191, 525-536.
20. Busby, T.F. and Ingham, K.C. (1980) Separation of Macromolecules by Ultrafiltration: J. Biochem. Biophys. Methods 2, 191-206.
29. Atha, D. and Ingham, K.C. (1981) Mechanism of Protein Precipitation by Polyethylene Glycol: Analysis in Terms of Excluded Volume, J. Biol. Chem. 256, 12108-12117.
32. Forastieri, H. and Ingham, K.C. (1982). Thermal Stability of Human Gonadotropins: Reversible Dissociation of Subunits at Neutral pH, J. Biol. Chem. 257, 7976-7981.
36. Forastieri, H. and Ingham, K.C. (1983) Fluid-Phase Interaction between Human Plasma Fibronectin and Gelatin Determined by Fluorescence Polarization, Arch. Biochem. Biophys. 227, 358-366.
41. Ingham, K.C., Brew, S.A. Broekelmann, T.J. and McDonald, J.A. (1984) Thermal Stability of Human Plasma Fibronectin and Its Constituent Domains, J. Bio. Chem. 259, 11901-11907.
44. Ingham, K.C., Landwehr, R. and Engel, J. (1985) Interaction of Fibronectin with C1q and Collagen: Effects of Ionic Strength and Denaturation of the Collagenous Component. Eur. J. Biochem. 148, 219-224.
47. Lennick, M., Brew, S.A. and Ingham, K.C. (1986) "Kinetics of Interaction of C1-Inhibitor with Complement C1, Biochemistry 25, 3890-3897.
48. Busby, T.F. and Ingham, K.C. (1987) Calcium Sensitive Thermal Transitions and Domain Structure of Human Complement Subcomponent C1, Biochemistry 26, 5564-5571.
54. Busby, T.F. and Ingham, K.C. (1990) The amino terminal calcium-binding domain of human complement C1s mediates the interaction of C1r with C1q, Biochemistry 29, 4613- 4618.
57. Litvinovich, S., Strickland, D., Medved, L. and Ingham, K. (1991) Domain Structure and interactions of the type I and type II modules in the gelatin-binding region of fibronectin: All six modules are independently folded, J. Mol. Biol. 217, 563-575.
58. Novokhatny, V.V., Ingham, K.C. and Medved, L.V. (1991) Domain structure and domain-domain interactions of recombinant tissue plasminogen activator, J. Biol. Chem. 266, 12994-13002.
63. Ingham, K.C., Milasincic, D.J., Busby, T.F. and Strickland, D.K. (1992) Dynamic Equilibria between subcomponents of C1, the first component of human complement, Molecular Immunology 29, 45-51.
69. Ward, S.L. and Ingham, K.C. (1992) A calcium-binding monoclonal antibody that recognizes a non-calcium-binding epitope in the short consensus repeat units (SCRs) of complement C1r, Mol. Immunol. 29, 83-93.
73. Radek, J.T., Jeong, J.-M., Murthy, S.N.P., Ingham, K.C. and Lorand, L. (1993) Affinity of human erythrocyte transglutaminase for a 42-kDa gelatin-binding fragment of human plasma fibronectin, Proc. Natl. Acad. Sci. USA 90, 3152-3156.
76. Ingham, K.C., Brew, S.A. and Migliorini, M. (1994) An unusual heparin-binding peptide from the carboxy-terminal hep-2 region of fibronectin, Arch. Biochem. Biophys. 314, 242-246.
80. Rivas, G., Ingham, K.C. and Minton, A.P. (1994) Ca2+-linked association of human complement Cls and Clr, Biochemistry 33, 2341-2348.
85. Litvinovich, S.V. and Ingham, K.C. (1995) Interactions between type III domains in the 110 kDa cell-binding region of fibronectin, J. Mol. Biol. 248, 611-626.
88. Busby, T.F., Argraves, W.S., Brew, S.A., Pechik, I. Gilliland, G.L. & Ingham, K.C. (1995) Heparin binding by fibronectin module III-13 involves six discontinuous basic residues brought together to form a cationic cradle, J.Biol.Chem. 270,18558-18562.
93. Ingham, K.C., Brew, S.A., Huff,S., & Litvinovich, S.V. (1997) Cryptic self-association sites in type III modules of fibronectin, J.Biol.Chem. 272, 1718-1724.
97. Litvinovich,S.V., Brew,S.A., Aota,S., Akiyama, S., Haudenschild,C., and Ingham, K.C. (1998) Formation of amyloid-like fibrils by self-association of a partially unfolded fibronectin type III module, J. Mol. Biol. 280,245-258.
99: Bloom, L., Ingham, K.C. and Hynes, R.O. (1999) Fibronectin regulates assembly of actin filaments and focal contacts in cultured cells via the heparin-binding site in repeat III13, Mol. Biol. Cell 10, 1521-1536.
100. Yakovlev, S., Makogonenko, E., Kurochkina, N., Nieuwenhuizen, W., Ingham, K. and Medved, L. (2000) Conversion of fibrinogen to fibrin: mechanism of exposure of tPA- and plasminogen-binding sites, Biochemistry 26, 15730-15741.
102. Ingham, K.C., Brew, S.A. and Migliorini, M (2002) Type I collagen contains at least 14 cryptic fibronectin binding sites of similar affinity, Arch. Biochem. Biophys. 407, 217-223.
103. Katagiri, Y., Brew, S.A. and Ingham, K.C. (2003) All six modules of the gelatinbinding domain of fibronectin are required for full affinity, J. Biol. Chem. 278.11897-11902.
105. Ingham, K.C., Brew, S., Vaz, D., Sauder, D.N., McGavin, M.J. (2004) Interaction of Staphylococcus aureus fibronectin-binding protein with fibronectin: affinity, stoichiometry, and modular requirements, J. Biol. Chem. 279,42945-42953.
106. Makogonenko, E., Ingham, K.C., and Medved, L. (2007) Interaction of the fibronectin COOH-terminal Fib-2 regions with fibrin: further characterization and localization of the Fib-2-binding sites, Biochemistry 46, 5418-5426.